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Related Concept Videos

CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

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Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
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Depressants01:28

Depressants

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Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
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Drug Dependence01:17

Drug Dependence

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Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
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Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
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Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

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Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
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Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

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Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
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Related Experiment Video

Updated: May 9, 2025

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:11

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

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Symptom-Triggered Alcohol Withdrawal Management Delivered Over Telemedicine.

Matthew E Sloan, Anthony Ngoy, Ke Bin Xiao

    Journal of Addiction Medicine
    |May 1, 2025
    PubMed
    Summary

    Telemedicine effectively managed alcohol withdrawal symptoms in a study, showing high completion rates and patient satisfaction. This approach could improve access to care, especially in underserved areas.

    Keywords:
    alcohol detoxificationalcohol use disorderalcohol withdrawalbenzodiazepinestelemedicine

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    Area of Science:

    • Addiction Medicine
    • Digital Health
    • Public Health

    Background:

    • Alcohol use disorder (AUD) is a major global health issue with limited access to evidence-based care.
    • Telemedicine interventions show promise for expanding treatment access, but validated options for alcohol withdrawal are lacking.

    Purpose of the Study:

    • To assess the feasibility of delivering symptom-triggered alcohol withdrawal management via telemedicine.
    • To evaluate patient retention, need for higher care, and satisfaction with the telemedicine protocol.

    Main Methods:

    • A single-arm study involving 30 participants with AUD undergoing 3 days of symptom-triggered withdrawal management.
    • Utilized the Clinical Institute Withdrawal Assessment for Alcohol Scale Revised (CIWA-Ar) delivered by clinicians over a telemedicine platform.

    Main Results:

    • High treatment completion rate of 93.3% with no participants requiring transfer to a higher level of care.
    • Excellent patient satisfaction reported, with an average Client Satisfaction Questionnaire-8 score of 30.9/32.
    • 56.7% of participants achieved alcohol abstinence at 30-day follow-up.

    Conclusions:

    • Telemedicine-based symptom-triggered alcohol withdrawal management is feasible and well-tolerated by patients.
    • Findings suggest potential for telemedicine to improve access to alcohol withdrawal services, particularly in remote or underserved regions.