Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LGBTQ+ Realities in the Biological Sciences.

CBE life sciences education·2026
Same author

Outcomes after elective total aortic arch replacement: Does obesity matter?

JTCVS open·2026
Same author

Mindful diagnostics in culture-negative endocarditis: early noninvasive diagnosis of <i>Tropheryma whipplei</i> by plasma microbial cell-free DNA.

Antimicrobial stewardship & healthcare epidemiology : ASHE·2026
Same author

Rethinking flow: the paradox of renoprotection without increased renal blood flow in cardiopulmonary bypass.

Journal of thoracic disease·2026
Same author

Concomitant bilateral lung transplantation and diaphragmatic hernia repair: A case report.

JTCVS techniques·2026
Same author

Ten-year outcomes of valve-replacing versus valve-sparing aortic root replacement in patients with Marfan syndrome: An observational multicenter study.

The Journal of thoracic and cardiovascular surgery·2026

Related Experiment Video

Updated: May 9, 2025

A Human-machine-interface Integrating Low-cost Sensors with a Neuromuscular Electrical Stimulation System for Post-stroke Balance Rehabilitation
11:06

A Human-machine-interface Integrating Low-cost Sensors with a Neuromuscular Electrical Stimulation System for Post-stroke Balance Rehabilitation

Published on: April 12, 2016

10.4K

Machine Learning Assisted Stroke Prediction in Mechanical Circulatory Support: Predictive Role of Systemic

Jacob P Scioscia1, Ivan Murrieta-Alvarez1, Shiyi Li1

  • 1From the Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|May 1, 2025
PubMed
Summary

Patients with prior stroke have mitochondrial dysfunction before LVAD implantation. This dysfunction, measured by oxidative phosphorylation proteins, may predict new strokes after CF-LVAD surgery.

Keywords:
heart failuremachine learningmechanical circulatory supportmitochondriaoxidative phosphorylationstroke

More Related Videos

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke
08:01

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Published on: July 10, 2014

11.4K
Author Spotlight: Enhancing Upper Limb Rehabilitation in Stroke Patients Through Advanced Robotic and Neuromodulation Technologies
05:28

Author Spotlight: Enhancing Upper Limb Rehabilitation in Stroke Patients Through Advanced Robotic and Neuromodulation Technologies

Published on: October 11, 2024

427

Related Experiment Videos

Last Updated: May 9, 2025

A Human-machine-interface Integrating Low-cost Sensors with a Neuromuscular Electrical Stimulation System for Post-stroke Balance Rehabilitation
11:06

A Human-machine-interface Integrating Low-cost Sensors with a Neuromuscular Electrical Stimulation System for Post-stroke Balance Rehabilitation

Published on: April 12, 2016

10.4K
Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke
08:01

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Published on: July 10, 2014

11.4K
Author Spotlight: Enhancing Upper Limb Rehabilitation in Stroke Patients Through Advanced Robotic and Neuromodulation Technologies
05:28

Author Spotlight: Enhancing Upper Limb Rehabilitation in Stroke Patients Through Advanced Robotic and Neuromodulation Technologies

Published on: October 11, 2024

427

Area of Science:

  • Cardiology
  • Neurology
  • Mitochondrial Biology

Background:

  • Stroke is a significant risk after continuous-flow left ventricular assist device (CF-LVAD) implantation in advanced congestive heart failure (CHF) patients.
  • Mitochondrial oxidative phosphorylation (OxPhos) abnormalities are linked to neurodegeneration and cerebral ischemia.

Purpose of the Study:

  • To investigate if prior stroke is associated with systemic mitochondrial OxPhos abnormalities in CF-LVAD patients.
  • To determine if these abnormalities are more pronounced in patients at risk for new strokes post-implantation.

Main Methods:

  • Studied 50 CF-LVAD patients (25 with prior stroke, 25 without).
  • Measured OxPhos complex proteins (C.I-C.V) in blood leukocytes pre- and post-CF-LVAD implantation.
  • Utilized machine learning (LASSO, Random Forest) for stroke prediction modeling.

Main Results:

  • The prior-stroke group showed significantly lower levels of C.I, C.II, C.IV, and C.V proteins compared to the no-prior-stroke group, both pre- and post-CF-LVAD.
  • OxPhos proteins significantly decreased in the prior-stroke group post-CF-LVAD compared to pre-CF-LVAD.
  • Machine learning models identified six prognostic factors, predicting postoperative stroke with an AUC of 0.93.

Conclusions:

  • Mitochondrial dysfunction, indicated by reduced OxPhos proteins, exists peripherally in CHF patients with prior stroke, even before CF-LVAD implantation.
  • Reduced OxPhos protein expression may serve as a biomarker for predicting new strokes after CF-LVAD implantation.