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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Related Experiment Video

Updated: May 9, 2025

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

Microfabricated Organ-Specific Models of Tumor Microenvironments.

Jeong Min Oh¹, Yongkuk Park², Jungwoo Lee^2,3,4

¹Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA;

Annual Review of Biomedical Engineering

|May 1, 2025

Summary

This summary is machine-generated.

Microfabricated tumor microenvironment (TME) models offer advanced in vitro cancer research tools, overcoming animal model limitations. These models, combined with single-cell omics, enhance understanding of tumor complexity for better cancer therapies.

Keywords:

MPS TME carcinogenesis metastasis microfabricated model microphysiological systems tumor microenvironment

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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

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Published on: September 20, 2016

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Last Updated: May 9, 2025

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

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Published on: April 30, 2021

Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research

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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

Area of Science:

Oncology
Biotechnology
Tissue Engineering

Background:

Cancer remains a significant global health challenge despite advances in detection and treatment.
Traditional animal models for cancer research have limitations in fully replicating human tumor complexity.
Microfabricated in vitro models are emerging as promising alternatives to study tumor microenvironments (TMEs).

Purpose of the Study:

To review recent advancements in microfabricated in vitro models of TMEs.
To highlight the integration of these models with single-cell omics technologies.
To discuss the potential of these models in accelerating the development of novel cancer therapeutics.

Main Methods:

Tissue engineering techniques to create organ- and patient-specific TMEs.
Microfabrication technologies for developing advanced in vitro cancer models.
Integration of next-generation single-cell omics technologies for detailed analysis.

Main Results:

Microfabricated TME models better reflect the physiological relevance of human tumors.
These models provide unprecedented insights into cellular and molecular heterogeneity.
Recent advances enable models that capture organ-specific characteristics of tumors.

Conclusions:

Microfabricated TME models are crucial for overcoming limitations of animal models.
Integration with omics technologies offers deeper understanding of cancer complexity.
These advanced models hold significant promise for developing more effective cancer treatments.