Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Calmodulin-dependent Signaling

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...

Feedback Regulation of Calcium Concentration

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...

ATP Driven Pumps II: P-type Pumps

ATP Driven Pumps II: P-type Pumps

The P-type pumps are a large family of integral membrane transporter ATPases. They are divided into five major types based on substrate specificity, from I to V.
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...

Roles of Electrolytes: Calcium and Phosphate

Roles of Electrolytes: Calcium and Phosphate

Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...

IP3/DAG Signaling Pathway

IP3/DAG Signaling Pathway

Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...

Skeleton and Calcium Homeostasis

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Nucleophilic Gallyl Anions Enable Ga─Au Bimetallic Ammonia Activation.

Angewandte Chemie (International ed. in English)·2026

Same author

Solvent-Dependent Carbon-to-Metal Hydrogen Atom Transfer Reactivity of a Square Planar Rhodium(II) Alkynyl Complex.

Organometallics·2026

Same author

A neutral cyclic aluminium (I) trimer.

Nature communications·2026

Same author

Dinitrogen Reduction by Titanium PCP Complexes.

Inorganic chemistry·2026

Same author

Thiosquaramides: dual-function ionophores for Zn<sup>2+</sup> and Cl<sup>-</sup> with ion dependent anti-microbial activity.

Organic & biomolecular chemistry·2025

Same author

A direct comparison of lithium tetra(<i>n</i>-butyl) manganate(II) and magnesiate: structural insights and catalytic hydroamination of styrenes.

Chemical communications (Cambridge, England)·2025

Search research articles

Related Experiment Video

Updated: May 23, 2025

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

Published on: June 16, 2022

PCP and POCOP complexes of calcium.

Alessandro Messori¹, Marcel Potocnik¹, Sara Belazregue¹

¹Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.

Chemical Communications (Cambridge, England)

|May 1, 2025

Summary

Researchers report the first synthesis of calcium complexes with PCP and POCOP ligands. These novel organometallic compounds pave the way for new calcium chemistry applications.

More Related Videos

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+

Published on: May 19, 2017

Automated Analysis of Dynamic Ca2+ Signals in Image Sequences

Automated Analysis of Dynamic Ca2+ Signals in Image Sequences

Published on: June 16, 2014

Related Experiment Videos

Last Updated: May 23, 2025

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

Published on: June 16, 2022

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+

Published on: May 19, 2017

Automated Analysis of Dynamic Ca2+ Signals in Image Sequences

Automated Analysis of Dynamic Ca2+ Signals in Image Sequences

Published on: June 16, 2014

Area of Science:

Organometallic Chemistry
Calcium Complexes
Ligand Synthesis

Background:

Calcium is an abundant and relatively non-toxic metal.
Development of new calcium complexes is crucial for expanding its applications in catalysis and materials science.
PCP and POCOP ligands offer unique coordination environments for metal centers.

Purpose of the Study:

To describe the first synthesis of PCP and POCOP complexes of calcium.
To characterize the resulting calcium complexes.
To explore the formation of homoleptic calcium complexes.

Main Methods:

Reaction of calcium bis(bis(trimethylsilyl)amide) with lithium PCP or POCOP reagents.
Isolation and characterization of the synthesized calcium complexes.
Investigation of ligand stoichiometry effects on complex formation.

Main Results:

Successful synthesis of heteroleptic complexes (PCP)Ca(N(SiMe3)2) (1a) and (POCOP)Ca(N(SiMe3)2) (1b).
Formation of homoleptic complex (POCOP)2Ca (2) from reaction with excess Li[POCOP].
Exclusive formation of homoleptic complex (iPrPOCOP)2Ca (3) with the (iPrPOCOP) ligand.

Conclusions:

The study demonstrates a viable route for synthesizing novel PCP and POCOP calcium complexes.
Ligand structure and stoichiometry play a key role in determining the outcome of calcium complex formation.
These findings expand the scope of calcium organometallic chemistry and provide access to new calcium compounds.