Related Experiment Video

Updated: May 9, 2025

In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells
09:20

In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells

Published on: July 23, 2010

15.7K

CK2 control of human papillomavirus life cycles

Apurva T Prabhakar1, Iain M Morgan1,2

  • 16889 Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry , Richmond, VA 23298, USA.

Biological Chemistry
|May 1, 2025
PubMed

Insights

Human papillomaviruses (HPVs) cause significant cancers and diseases. This review highlights the host enzyme CK2 as a critical target for developing new anti-viral therapies against HPV infections and lesions.

Area of Science:

  • Virology
  • Oncology
  • Biochemistry

Background:

  • Human papillomaviruses (HPVs) are linked to approximately 5% of all human cancers.
  • Current prophylactic vaccines address future HPV burdens, but effective therapeutic anti-viral strategies for existing infections and lesions are lacking.
  • HPVs manipulate host epithelial cell proliferation and differentiation for viral life cycle completion.

Purpose of the Study:

  • To review the critical role of the host enzyme Casein Kinase 2 (CK2) in regulating HPV viral proteins.
  • To identify CK2 as a key enzyme controlling HPV life cycles.
  • To explore therapeutic strategies targeting CK2 for combating HPV infections and diseases.

Main Methods:

  • Literature review focusing on viral-host interactions in HPV life cycles.
  • Analysis of the regulatory role of CK2 on HPV proteins E1, E2, and E7.
  • Summary of potential therapeutic interventions targeting CK2 function.

Main Results:

  • The host enzyme CK2 plays a critical role in regulating the function of HPV proteins E1, E2, and E7.
  • CK2 activity is essential for the successful progression of the HPV life cycle.
  • Understanding CK2's role provides a basis for novel therapeutic approaches.

Conclusions:

  • CK2 is a crucial host factor essential for HPV replication and pathogenesis.
  • Targeting CK2 offers a promising therapeutic avenue for treating HPV infections and associated diseases.
  • Further research into CK2-targeted therapies could lead to effective treatments for HPV-related conditions.
Keywords:
CK2E1E2E7HPVlife-cycle

More Related Videos

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus09:53

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus

Published on: August 25, 2017

8.2K
Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus13:41

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Published on: March 8, 2012

12.3K

Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.5K
S-Cdk Initiates DNA Replication02:38

S-Cdk Initiates DNA Replication

The cell cycle is a series of events leading to DNA duplication followed by the division of cell content to form two daughter cells. The cell cycle progresses in four stages—the cell increases in size (gap 1 or G1-phase), duplicates its DNA (synthesis or S-phase), prepares to divide (gap 2 or G2-phase), and divides (mitosis or M-phase).
Two states at the origin of replication
In eukaryotes, the initiation of replication occurs at many sites on the chromosomes, called the origins of...
4.6K
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.3K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
35.0K
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
5.2K
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
2.9K