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Preoperative prediction of Ki-67 expression in medullary thyroid carcinoma based on ultrasonographic features: a

Qianru Zhang1, Yan Hu1, Xiaoyan Chen2

  • 1Department of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

European Journal of Radiology
|May 1, 2025
PubMed
Summary
This summary is machine-generated.

Ultrasonography can predict high Ki-67 expression in medullary thyroid carcinoma (MTC). Features like upper/middle location, larger tumor size (>2.15 cm), and marked hypoechogenicity indicate higher Ki-67 levels.

Keywords:
Ki-67Medullary thyroid carcinomaRetrospective studyUltrasound

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Area of Science:

  • Oncology
  • Radiology
  • Pathology

Background:

  • Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor.
  • Ki-67 expression is a prognostic marker in MTC.
  • Accurate prediction of Ki-67 levels preoperatively is clinically valuable.

Purpose of the Study:

  • To identify ultrasonographic features associated with high Ki-67 expression in MTC.
  • To develop a predictive model for Ki-67 levels in MTC nodules.

Main Methods:

  • Retrospective analysis of 210 MTC patients (245 nodules).
  • Clinical and ultrasonographic data were analyzed.
  • Multivariate logistic regression identified risk factors for Ki-67 ≥ 5%.
  • A prediction model was built and validated using AUC.

Main Results:

  • High Ki-67 expression (≥ 5%) was observed in 41 nodules, low expression (< 5%) in 204 nodules.
  • Independent risk factors for high Ki-67 included upper/middle location, tumor size > 2.15 cm, and marked hypoechogenicity.
  • The prediction model achieved an AUC of 0.812.

Conclusions:

  • Specific ultrasound features can predict high Ki-67 expression in MTC.
  • The developed prediction model shows good diagnostic performance.
  • These findings may aid in preoperative risk stratification for MTC.