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Related Experiment Video

Updated: May 12, 2025

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Clinical Validation of a Noninvasive Multi-Omics Method for Multicancer Early Detection in Retrospective and

Shiyong Li1, Shuaipeng Geng2, Yan Chen1

  • 1Research and Development, SeekIn Inc., Shenzhen, China.

The Journal of Molecular Diagnostics : JMD
|May 1, 2025
PubMed
Summary
This summary is machine-generated.

A new multi-omics blood test, SeekInCare, shows promise for early cancer detection. It analyzes cell-free DNA and protein markers to identify cancer in asymptomatic individuals, aiding in early diagnosis and treatment.

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Area of Science:

  • Oncology
  • Genomics
  • Biomarker Discovery

Background:

  • Blood-based multicancer early detection (MCED) tests are emerging but often focus on single cancer hallmarks, limiting efficacy due to tumor heterogeneity.
  • Existing MCED approaches may not fully capture the complexity of cancer detection.

Purpose of the Study:

  • To report on SeekInCare, a novel blood-based multi-omics test designed for comprehensive MCED.
  • To evaluate the performance of SeekInCare in detecting various cancer types and stages.

Main Methods:

  • SeekInCare integrates shallow whole-genome sequencing of cell-free DNA (cfDNA) and seven protein tumor markers.
  • It analyzes multiple genomic and epigenetic hallmarks: copy number aberration, fragment size, end motif, and oncogenic virus.
  • Artificial intelligence (AI) algorithms were developed for cancer detection and organ prediction.

Main Results:

  • In a retrospective study (617 cancer patients, 580 controls), SeekInCare achieved 60.0% sensitivity and 98.3% specificity (AUC 0.899) across 27 cancer types.
  • Sensitivity increased with cancer stage (37.7% Stage I to 78.1% Stage IV).
  • In a prospective cohort (1203 individuals), the test demonstrated 70.0% sensitivity and 95.2% specificity.

Conclusions:

  • SeekInCare is a validated blood-based MCED test with performance comparable to other developmental tests.
  • The findings support SeekInCare's potential clinical utility for cancer screening in high-risk populations.