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NDR2 kinase: A review of its physiological role and involvement in carcinogenesis

Tiphaine Biojout1, Emmanuel Bergot2, Benoit Bernay3

  • 1Université de Caen Normandie, CNRS, Normandie Université, ISTCT UMR6030, GIP CYCERON, F-14000 Caen, France.

International Journal of Biological Macromolecules
|May 1, 2025
PubMed

Insights

The Hippo kinase NDR2 is crucial in lung cancer progression, regulating key cell processes. Understanding its interactions offers potential new anticancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • The Hippo kinase, NDR2, is implicated in the progression of various human cancers, notably lung cancer.
  • NDR2 regulates critical cellular processes including proliferation, apoptosis, migration, invasion, vesicular trafficking, autophagy, ciliogenesis, and immune response.

Purpose of the Study:

  • To investigate the specific actions, interactions, and functions of NDR2 in physiological and tumoral contexts, particularly lung cancer.
  • To explore structural differences between NDR1 and NDR2 and their correlation with distinct post-translational regulation and functions.
  • To identify NDR2 partners and substrates for potential anticancer therapeutic strategies.

Main Methods:

  • Comparative analysis of amino acid sequences between NDR1 and NDR2.
  • Proteomic comparison of NDR1 versus NDR2 interactomes in human bronchial epithelial cells (HBEC-3), lung adenocarcinoma cells (H2030), and their brain metastasis-derived counterparts (H2030-BrM3).
  • Analysis of potential clustering and functional enrichment networks among NDR2-specific interactants.

Main Results:

  • Structural differences between NDR1 and NDR2 correlate with distinct post-translational regulation and functions.
  • NDR2 plays a pivotal role in cancer progression, especially in lung cancer.
  • Proteomic data provides insights into NDR1/NDR2 interactomes in relevant lung cancer cell models.

Conclusions:

  • NDR2 is a key regulator in cancer, particularly lung cancer, with distinct functions compared to NDR1.
  • Identifying NDR2 partners and substrates is crucial for understanding its role in normal and tumor contexts.
  • Further research into NDR2 and its interactants may reveal novel anticancer therapeutic targets.
Keywords:
Hippo pathwayLung cancerNDR2Therapeutic targetcancer

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