Search research articles

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Inhibition of runt related transcription factor 1 with Ro24-7429 improves lung function in experimental models of idiopathic pulmonary fibrosis.

Scientific reports·2026

Same author

A digestive cartridge reduces intestinal injury in a murine model of necrotizing enterocolitis.

PloS one·2026

Same author

Downregulation of pigment epithelium-derived factor increases compensatory lung growth in mice after extended pneumonectomy.

Pediatric research·2026

Same author

In defense of the Holman index: Defining fatty acid deficiency.

Nutrition (Burbank, Los Angeles County, Calif.)·2026

Same author

Vascular dysfunctions during radiation retinopathy.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2025

Same author

The Eastern Pediatric Surgery Network: Creation and implementation of a comprehensive clinical research collaborative in pediatric surgery.

Journal of clinical and translational science·2025

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 9, 2025

Intravenous Injections in Neonatal Mice

Intravenous Injections in Neonatal Mice

Published on: November 11, 2014

Systemic heparin administration impairs lung development in neonatal mice.

Thomas I Hirsch^1,2, Savas T Tsikis^1,2, Scott C Fligor^1,2

¹Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

Scientific Reports

|May 1, 2025

Summary

Heparin administration during the saccular stage of lung development in neonatal mice negatively impacts lung growth, causing emphysema. Late heparin exposure did not affect lung development, suggesting a critical developmental window for heparin

More Related Videos

A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease

A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease

Published on: August 4, 2021

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin

Published on: April 30, 2019

Related Experiment Videos

Last Updated: May 9, 2025

Intravenous Injections in Neonatal Mice

Intravenous Injections in Neonatal Mice

Published on: November 11, 2014

A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease

A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease

Published on: August 4, 2021

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin

Published on: April 30, 2019

Area of Science:

Neonatal physiology
Pulmonary medicine
Pharmacology

Background:

Preterm infants face bronchopulmonary dysplasia (BPD) risk due to saccular stage lung development.
Oxygen toxicity and volutrauma are known BPD contributors, yet chronic lung disease persists.
Heparin, commonly used in neonates, interferes with angiogenesis, crucial for lung development.

Purpose of the Study:

To investigate the impact of heparin on neonatal lung development during the saccular phase.
To determine if early-life heparin exposure affects lung structure and function in mice.

Main Methods:

Newborn C57BL/6J mice received unfractionated heparin (UFH), low molecular weight heparin (LMWH), or saline (control) for the first week.
Lung phenotype was assessed at one month of age.
Heparin administration after the saccular phase was also evaluated.

Main Results:

Both UFH and LMWH administered during the first week resulted in an emphysematous lung phenotype at one month.
Late heparin administration, post-saccular phase, did not impact lung function or growth.
Heparin interferes with critical postnatal lung development.

Conclusions:

Heparin negatively affects lung development when administered during the critical saccular phase in neonatal mice.
These findings highlight potential risks of early-life heparin exposure in preterm infants.
Clinical studies are warranted to investigate heparin's impact on infant lung development.