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Updated: May 9, 2025

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice
Published on: March 3, 2023
Emergence of orthogonal hippocampal representations during spatial learning
1Department of Psychology and J. P. Scott Center for Neuroscience, Mind and Behavior, Bowling Green State University, Bowling Green, OH, USA. vbingma@bgsu.edu.
Abstract:
Sun et al. (2025) reveal the progressive, dynamic changes in the response properties of thousands of hippocampal neurons as mice learn a conditional discrimination while moving along a virtual linear track. At the end of training, separate orthogonalized ensemble codes, reflecting the properties of a state machine, capture the inherent structure of the task while dissociating the discrimination outcomes.
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