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Spatial R wave amplitude changes during exercise: relation with left ventricular ischemia and function.

J Myers, S Ahnve, V Froelicher

    Journal of the American College of Cardiology
    |September 1, 1985
    PubMed
    Summary
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    Changes in spatial R wave amplitude during exercise testing do not correlate with left ventricular function or indicators of ischemia. This finding suggests spatial R wave amplitude changes are not reliable markers for assessing coronary artery disease severity during exercise.

    Area of Science:

    • Cardiology
    • Exercise Physiology
    • Biomedical Engineering

    Background:

    • Spatial R wave amplitude is a measure derived from electrocardiogram (ECG) signals.
    • Its changes during exercise may indicate cardiac issues, but its relationship with left ventricular function and ischemia is not fully understood.

    Purpose of the Study:

    • To investigate the relationship between spatial R wave amplitude changes during exercise and left ventricular function and ischemic variables in patients with stable coronary artery disease.

    Main Methods:

    • Compared spatial R wave amplitude changes in patients with increased versus decreased amplitude during exercise.
    • Analyzed differences in oxygen consumption, ECG changes (ST depression), left ventricular ejection fraction (LVEF), and thallium-201 ischemia.
    • Patients were stratified by maximal heart rate achieved during exercise.

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    Main Results:

    • Significant differences were found only in exercise-induced spatial R wave amplitude changes (p < 0.0001).
    • No significant correlation was observed between heart rate changes and spatial R wave amplitude changes.
    • Spatial R wave amplitude changes did not correlate with ischemic ECG changes, thallium-201 imaging, or LVEF.

    Conclusions:

    • Exercise-induced changes in spatial R wave amplitude are not associated with left ventricular function or ischemic changes in patients with stable coronary artery disease.
    • Spatial R wave amplitude is not a reliable indicator for assessing ischemia or ventricular function during exercise stress tests.