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Renal oncocytoma in a chimpanzee
Elliott S Chiu1,2, William Vernau1, Anibal G Armién1,3
1Department of Pathology, Microbiology, and Immunology, University of California-Davis, Davis, CA, USA.
Summary
A large renal mass in a chimpanzee was diagnosed as an oncocytoma, a benign kidney tumor. This finding is significant as it is the first reported case in a great ape and closely resembles human oncocytomas.
Area of Science:
- Veterinary Pathology
- Primate Oncology
- Comparative Pathology
Background:
- Renal masses are uncommon in non-human primates.
- Oncocytomas are benign kidney tumors typically found in humans.
- This study details a novel case in a great ape.
Purpose of the Study:
- To report the first documented case of renal oncocytoma in a chimpanzee (Pan troglodytes).
- To characterize the histological and ultrastructural features of the tumor.
- To compare the findings with human renal oncocytomas.
Main Methods:
- Ultrasound and cytology for initial mass identification and characterization.
- Surgical resection and gross pathological examination of the renal mass.
- Histopathology with immunohistochemistry (cKIT, CK7) and transmission electron microscopy for definitive diagnosis.
Main Results:
- A large renal mass was identified and surgically removed.
- Cytology showed neoplastic polygonal cells with granular cytoplasm.
- Histology and immunohistochemistry confirmed the diagnosis of oncocytoma, with electron microscopy identifying mitochondria as the granular component.
Conclusions:
- This is the first reported case of renal oncocytoma in a great ape.
- The chimpanzee oncocytoma shares morphological and immunohistochemical similarities with human counterparts.
- This case contributes to the comparative understanding of renal neoplasms in primates.
