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Physical exercise promotes white matter repair after ischemic stroke
Yating Mu1, Xiaofeng Yang, Yifeng Feng
1Department of Rehabilitation Medicine, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Neural Regeneration Research
|May 2, 2025
Summary
Physical exercise enhances white matter repair after stroke by boosting regulatory T (Treg) cells. These cells promote recovery and reduce inflammation, with osteopontin and CXCL12-CXCR4 signaling playing key roles.
Area of Science:
- Neuroscience
- Immunology
- Regenerative Medicine
Background:
- White matter injury significantly impairs stroke recovery.
- Physical exercise shows potential for promoting white matter repair.
- The role of regulatory T (Treg) cells in white matter integrity post-stroke is not well understood.
Purpose of the Study:
- To investigate the mechanism by which physical exercise promotes white matter repair after ischemic stroke.
- To elucidate the role of regulatory T (Treg) cells in exercise-induced white matter repair.
Main Methods:
- Established a transient middle cerebral artery occlusion male mouse model.
- Assessed the effects of physical exercise and Treg cell depletion on neurological recovery, neuroinflammation, myelin debris clearance, and white matter repair.
- Investigated the roles of osteopontin, the CXCL12-CXCR4 axis, and Treg-conditioned medium in the observed effects.
Main Results:
- Physical exercise increased brain Treg cells, leading to improved neurological recovery, reduced neuroinflammation, enhanced myelin debris clearance, and accelerated white matter repair.
- Depletion of Treg cells diminished the beneficial effects of physical exercise.
- Osteopontin levels and the CXCL12-CXCR4 axis were identified as key mediators in the Treg cell-dependent repair process.
Conclusions:
- Physical exercise promotes white matter repair following ischemic stroke primarily through the action of regulatory T (Treg) cells.
- The findings highlight the therapeutic potential of targeting Treg cells and associated signaling pathways for stroke recovery.
- The study elucidates a novel mechanism involving Treg cells, osteopontin, and the CXCL12-CXCR4 axis in exercise-mediated neuroprotection and repair.
Keywords:
CXCL12Treg cellsischemic strokemicroglianeuroinflammationosteopontinphagocytosisphysical exercisetransient middle cerebral artery occlusionwhite matter injuryMore Related Videos
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