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Relationships between MMP-2, MMP-9, and ADAMDEC1 serum and tissue levels in patients with colorectal cancer

  • 0Antimicrobial Resistance Research Center, Institute of Immunology, and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
Annals of Coloproctology +

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May 2, 2025

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May 2, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Matrix metalloproteinases (MMPs) and ADAMDEC1 show elevated expression in colorectal cancer (CRC) tissues. These genes are promising diagnostic biomarkers for early CRC detection and assessing lymphovascular invasion.

Area Of Science

  • Oncology
  • Molecular Biology
  • Biochemistry

Background

  • Colorectal cancer (CRC) is a prevalent global malignancy.
  • Early diagnosis of CRC is crucial for effective treatment.
  • Matrix metalloproteinases (MMPs) and ADAMDEC1 are implicated in cancer progression.

Purpose Of The Study

  • To investigate serum levels of MMP-2 and MMP-9.
  • To analyze tissue expression of MMP-2, MMP-9, and ADAMDEC1 in CRC.
  • To explore associations between these markers and CRC pathological/clinical factors.

Main Methods

  • Enzyme-linked immunosorbent assay (ELISA) for serum MMP-2 and MMP-9.
  • Quantitative real-time polymerase chain reaction (qRT-PCR) for tissue gene expression.
  • Comparison of 100 CRC patients with 100 controls.

Main Results

  • MMP-2, MMP-9, and ADAMDEC1 were significantly upregulated in CRC tissues versus controls.
  • Expression levels correlated with lymphovascular invasion (P<0.001).
  • Receiver operating characteristic (ROC) curve analysis indicated diagnostic potential.

Conclusions

  • MMP-2, MMP-9, and ADAMDEC1 show promise as diagnostic biomarkers for CRC.
  • These markers may aid in identifying patients with specific pathological features like lymphovascular invasion.

Keywords: