Related Experiment Video
Updated: Jun 17, 2026
In vivo 19F MRI for Cell Tracking
Published on: November 25, 2013
An in-vivo approach to quantify intra-MRI head motion tracking accuracy: comparison of markerless optical tracking
Purpose:
Head-motion tracking and correction remains a key area of research in MRI, but the lack of rigorous and standardized evaluation approaches hinders their optimization and comparison. We introduce an in-vivo framework for assessing the accuracy of intra-MRI head motion tracking, and demonstrates its effectiveness by comparing two methods based on a markerless optical system (MOS) and a fat signal navigator (FatNav).
Methods:
Six participants underwent 3T brain MRI using a T1-weighted (T1w) pulse-sequence with a fat- navigator module. Participants performed head-rotations of 2° or 4°, each visually guided by MOS feedback around a single primary axis (X or Z). MOS and FatNav estimations were evaluated against rigid-registration of T1w-images, as gold-standard, across seven different head positions.
Results:
The proposed approach revealed that MOS outperforms FatNav in estimating translation and large head rotations (2-4°), while FatNav shows better accuracy for subtle rotations. Image quality assessments following correction for three head rotations (rightward, upward, and leftward) confirmed that MOS outperformed FatNav in restoring image fidelity, as evidenced by the higher Structural Similarity Index, Peak Signal-to-Noise Ratio, and Focus Measure. Unlike the traditional image quality- based comparisons, the proposed framework demonstrated sensitivity to subtle improvements in FatNav performance, achieved by applying a neck mask to the fat-navigator images.
Conclusion:
The proposed framework enabled a precise in-vivo evaluation and comparison of MOS and FatNav for head-motions estimation. It was sufficiently sensitive to reveal a slight improvement in FatNav performance when neck was masked in fat-navigator images. In parallel, the conventional image quality-based approach confirmed the superior performance of MOS in restoring T1W image quality, though it did not capture the improvement achieved by FatNav with neck-masking. Together, these two complementary approaches provide a comprehensive assessment of both head-motions estimation and correction in MRI.
