Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

3.3K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.3K
Polygenic Traits01:18

Polygenic Traits

64.3K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
64.3K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

12.1K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
12.1K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.5K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.5K
Bone Structure01:55

Bone Structure

47.8K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
47.8K
Nature and Nurture01:10

Nature and Nurture

20.3K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cross-trait clustering of sub-threshold sleep genetic signals identifies EGR2 as a conserved regulator of sleep.

bioRxiv : the preprint server for biology·2026
Same author

Functionally informed annotation influences pathway-specific polygenic risk and disease inference in Alzheimer's disease.

medRxiv : the preprint server for health sciences·2026
Same author

Integrative genomics and single-cell CRISPRi screening dissect Alzheimer GWAS non-coding variants regulating TSPAN14.

American journal of human genetics·2026
Same author

Clinical Presentation and Outcomes of Insulinomas in Pediatric Patients.

Hormone research in paediatrics·2026
Same author

Geometry of the proximal femur during growth and its contribution to childhood fractures in healthy children.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

Insulin Hypersecretion and Increased Ectopic Fat in South Asian American Adolescents and Young Adults Compared With White and African American Peers: The CHARISMA Study.

Diabetes care·2026

Related Experiment Video

Updated: May 12, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

17.4K

The gSOS Polygenic Score is Associated with Bone Density and Fracture Risk in Childhood.

Jonathan A Mitchell1,2, Jonathan Bradfield3,4,5, Shana E McCormack2,6

  • 1Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia.

Medrxiv : the Preprint Server for Health Sciences
|May 2, 2025
PubMed
Summary

The genetic risk score (gSOS) for bone health is linked to better bone density and fewer fractures in children. This genetic tool may help improve children's bone health and prevent fractures throughout life.

More Related Videos

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
09:02

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

351
Preparation Of Gushukang GSK Granules for In Vivo and In Vitro Experiments
06:16

Preparation Of Gushukang GSK Granules for In Vivo and In Vitro Experiments

Published on: May 9, 2019

7.5K

Related Experiment Videos

Last Updated: May 12, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

17.4K
Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
09:02

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

351
Preparation Of Gushukang GSK Granules for In Vivo and In Vitro Experiments
06:16

Preparation Of Gushukang GSK Granules for In Vivo and In Vitro Experiments

Published on: May 9, 2019

7.5K

Area of Science:

  • Pediatric bone health research
  • Genetics and personalized medicine
  • Quantitative ultrasound and bone densitometry

Background:

  • The polygenic risk score for genetic quantitative ultrasound speed of sound (gSOS) was developed in adults and linked to fracture risk.
  • Understanding the association of gSOS with bone health in pediatric populations is crucial for early intervention.

Purpose of the Study:

  • To investigate the association between gSOS and bone health indicators in children.
  • To evaluate gSOS as a potential predictor of fracture risk in pediatric cohorts.

Main Methods:

  • Utilized genetic data from two independent pediatric cohorts: the Bone Mineral Density in Childhood Study (BMDCS) and Children's Hospital of Philadelphia (CHOP).
  • Calculated gSOS using genetic variants and assessed areal bone mineral density (aBMD) via DXA scans and fracture data from electronic health records.
  • Analyzed associations between gSOS, aBMD Z-scores, and fracture likelihood, adjusting for relevant covariates.

Main Results:

  • Higher gSOS scores were significantly associated with increased aBMD Z-scores across multiple skeletal sites in children.
  • A 1 SD increase in gSOS correlated with a 12-16% reduced likelihood of fracture in both pediatric cohorts.
  • These associations remained consistent across different sexes, ages, puberty stages, and lifestyle factors, particularly in European ancestry.

Conclusions:

  • The gSOS is associated with improved bone mineral density and reduced fracture risk in children.
  • This genetic risk score demonstrates potential clinical utility for enhancing early-life bone health and mitigating fracture risk across the lifespan.
  • gSOS may serve as a valuable genetic tool for personalized bone health management in pediatric populations.