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Imaging the centenarian brain. A computed tomographic study.

S J Goldstein, D R Wekstein, C Kirkpatrick

    Journal of the American Geriatrics Society
    |September 1, 1985
    PubMed
    Summary
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    Brain scans of centenarians revealed significant cerebral atrophy, varying widely regardless of sex, alcohol, or hypertension. The relationship between this aging brain change and cognitive function in the elderly remains unclear.

    Area of Science:

    • Gerontology
    • Neurology
    • Radiology

    Background:

    • Centenarians represent a unique population for studying aging.
    • Cerebral atrophy is a common finding in the elderly.
    • The impact of lifestyle factors on brain structure in extreme longevity is not fully understood.

    Purpose of the Study:

    • To investigate the degree of cerebral atrophy in healthy centenarians.
    • To explore the relationship between cerebral atrophy and factors like sex, alcohol consumption, and hypertension in this age group.

    Main Methods:

    • Cranial computed tomography (CT) scans were performed on ten healthy centenarians (aged 100-102 years).
    • Data on sex, alcohol use, and systolic blood pressure were collected.
    • CT findings were analyzed for the degree of cerebral atrophy and white matter lucency.

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    Main Results:

    • Considerable variation in cerebral atrophy was observed among centenarians.
    • Cerebral atrophy showed no correlation with sex, daily alcohol use, or hypertension (systolic blood pressure ≥ 160 mmHg).
    • Mild periventricular white matter lucency was present in three subjects.

    Conclusions:

    • Cerebral atrophy varies significantly in healthy centenarians.
    • Common lifestyle factors do not appear to correlate with the degree of atrophy in this cohort.
    • The precise link between progressive cerebral atrophy and cognitive function in advanced aging requires further investigation.