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  11. Intestinal Injury And Changes Of The Gut Microbiota After Ischemic Stroke

Intestinal injury and changes of the gut microbiota after ischemic stroke

Yang Shen1,2, Jin Wang1,2, Yina Li3

  • 1Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.

Frontiers in Cellular Neuroscience
|May 2, 2025

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Murine Model of Intestinal Ischemia-reperfusion Injury
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View abstract on PubMed

Summary
This summary is machine-generated.

Ischemic stroke (IS) damages the gut, altering gut bacteria and increasing disease severity. Protecting the gut barrier and modulating gut microbiota can improve outcomes for IS patients.

Area of Science:

  • Neurology
  • Gastroenterology
  • Microbiology

Background:

  • Ischemic stroke (IS) is a leading cause of death and disability globally.
  • IS significantly impacts the gut, compromising intestinal barrier integrity and altering gut microbiota composition.

Purpose of the Study:

  • To review current research on intestinal damage, gut microbiota changes, and therapeutic strategies following IS.
  • To highlight the gut's role in IS pathogenesis and recovery.

Main Methods:

  • Literature review of recent studies on IS and its effects on the gastrointestinal system.
  • Analysis of research on gut microbiota alterations, including bacterial composition and metabolite production.

Main Results:

  • IS increases intestinal permeability and allows gut bacteria translocation, triggering systemic inflammation.
Keywords:
gut microbiotaindividualized therapyintestinal injuryischemic stroke

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  • Gut microbiota shifts towards harmful bacteria, reducing beneficial metabolites like short-chain fatty acids (SCFAs) and increasing harmful ones like trimethylamine N-oxide (TMAO).
  • Therapies like antibiotics and nutritional support can positively influence gut microbiota and neurological recovery, while reperfusion injury may harm the gut.

    • Conclusions:

    • Intestinal damage and gut dysbiosis are critical factors in IS development and prognosis.
    • Targeting the gut mucosa and microbiota offers promising therapeutic strategies to improve IS patient outcomes.
    • Individualized treatment approaches are essential for managing IS patients effectively.
    stroke