Seroprevalence and Risk Factors of Hepatitis B Virus Among Newly Diagnosed Cancer Patients in Khartoum State: Implications for Chemotherapy Management and Screening Protocols
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View abstract on PubMed
Summary
This summary is machine-generated.Hepatitis B virus (HBV) seroprevalence was 10.3% in newly diagnosed cancer patients in Khartoum, Sudan. Blood transfusion history and geographic origin were significant risk factors for HBV infection in this population.
Area Of Science
- Oncology
- Infectious Diseases
- Public Health
Background
- Hepatitis B virus (HBV) infection poses a significant global health challenge, particularly in vulnerable populations.
- Cancer patients undergoing chemotherapy are at increased risk of HBV reactivation.
- Understanding HBV seroprevalence in newly diagnosed cancer patients is crucial for proactive management.
Purpose Of The Study
- To determine the seroprevalence of Hepatitis B virus (HBV) in newly diagnosed cancer patients in Khartoum State, Sudan.
- To identify risk factors associated with HBV infection in this cohort prior to chemotherapy.
- To inform screening protocols for oncology patients.
Main Methods
- A cross-sectional study involving 300 newly diagnosed cancer patients (≥18 years) in Khartoum State.
- Blood samples screened for Hepatitis B surface antigen (HBsAg) using rapid immunochromatographic test (ICT) and confirmed by ELISA.
- Statistical analysis to identify correlations between HBV positivity and demographic/clinical factors.
Main Results
- The overall HBV seroprevalence was 10.3% (31/300 patients).
- Significant associations were found between HBV positivity and history of blood transfusions (41.9%), specific geographic origins (Western and Central Sudan), and hematological malignancies.
- Key risk factors identified include age, gender, residence, and transfusion history.
Conclusions
- A notable prevalence of HBV was observed in cancer patients in Khartoum, linked to transfusion history and regional factors.
- Routine HBV screening is recommended for oncology patients before chemotherapy initiation to prevent reactivation and improve outcomes.
- Findings highlight the need for targeted public health interventions in specific regions of Sudan.
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