Related Experiment Video
Updated: May 9, 2025
09:17
Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates
Published on: March 5, 2019
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Designing atomically precise gold nanocluster architectures with DNA-guided self-assembly and biofunctionalization
Abdallah Alhalabi1,2, Christine Saint-Pierre2, Elisabetta Boeri-Erba3
1Université Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institut pour l'Avancée des Biosciences (IAB), Cancer Targets & Experimental Therapeutics, 38000 Grenoble, France. xavier.le-guevel@univ-grenoble-alpes.fr.
Nanoscale
|May 2, 2025
Summary
Atomically precise gold nanoclusters (AuNCs) were engineered with DNA for precise assembly. This enables the creation of novel AuNC-DNA superstructures for optoelectronics, sensing, and nanomedicine applications.
Area of Science:
- Nanotechnology
- Materials Science
- Biochemistry
Background:
- Atomically precise gold nanoclusters (AuNCs) possess unique optoelectronic properties.
- Their assembly and functionalization are key for advanced applications.
Purpose of the Study:
- To demonstrate precise ligand engineering of AuNCs for controlled oligonucleotide grafting.
- To create size-tunable AuNCs (Au18 and Au25) emitting in NIR-I and NIR-II spectral windows.
- To establish a foundation for AuNC-DNA superstructures.
Main Methods:
- Ligand engineering of AuNCs.
- Grafting of single-stranded oligonucleotides onto Au18 and Au25.
- Characterization using spectroscopy, mass spectrometry, chromatography, and gel electrophoresis.
- Assembly of AuNCs via DNA hybridization.
Main Results:
- Successful grafting of oligonucleotides onto Au18 and Au25 AuNCs.
- Characterization confirmed the structure and properties of biofunctionalized AuNCs.
- High-yield, reproducible assembly of AuNC dimers, trimers, and AuNC-dye systems.
Conclusions:
- Precise ligand engineering enables the creation of nanomolecular building blocks from AuNCs.
- DNA hybridization is an effective strategy for assembling AuNC-DNA superstructures.
- These superstructures hold promise for optoelectronics, sensing, and nanomedicine.
