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Cognitive and neural abnormalities: working memory deficits in bipolar disorder offspring

Ye Xie1,2,3, Wenjin Zou4, Yuanqi Shang3

  • 1School of Psychology, Shenzhen University, Shenzhen, P.R. China.

Psychological Medicine
|May 2, 2025
PubMed

Insights

Children of parents with bipolar disorder (BD) show working memory deficits. Brain imaging reveals altered neural connectivity in BD offspring, suggesting early signs of the disorder.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Offspring of parents with bipolar disorder (BD) have increased risks for emotional dysregulation and cognitive deficits.
  • Working memory impairments are a notable concern in this population.

Purpose of the Study:

  • To investigate working memory deficits in BD offspring.
  • To identify the neural correlates associated with these deficits using functional magnetic resonance imaging (fMRI).

Main Methods:

  • Assessed 41 BD offspring and 25 healthy controls (HCs) using a spatial N-back task.
  • Utilized task-related fMRI to examine brain activity and connectivity.

Main Results:

  • BD offspring demonstrated reduced accuracy and sensitivity on the 1-back task compared to HCs.
  • fMRI showed hyperactivation in the right intracalcarine cortex/lingual gyrus (ICC/LG) in BD offspring.
  • Reduced connectivity was observed between the right ICC/LG and left postcentral gyrus, and within dorsolateral prefrontal cortex (DLPFC) networks in BD offspring as task load increased.

Conclusions:

  • BD offspring exhibit working memory deficits linked to impaired neural connectivity.
  • These neural alterations may represent genetically predisposed markers for bipolar disorder.
  • Highlights the importance of early identification and intervention strategies for at-risk individuals.
Abstract

Keywords:
BD offspringbipolar disorderfunctional magnetic resonance imagingprefrontal cortexworking memory

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