Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Eliminating the Interference of Neighboring Nucleobases in Aerolysin for Nanopore Sequencing.

ACS sensors·2025

Same author

Single-molecule evidence of Entropic Pulling by Hsp70 chaperones.

Nature communications·2024

Same author

Deep Learning-Assisted Single-Molecule Detection of Protein Post-translational Modifications with a Biological Nanopore.

ACS nano·2023

Same journal

How Much Chirality is Enough?

Chimia·2026

Same journal

Raman Optical Activity (ROA) as an Emerging Standard in Molecular Chirality Measurements - A Perspective.

Chimia·2026

Same journal

Molecular Chirality: From Structure to the Quantum Dynamics of Tunnelling, Parity Violation, a Molecular Quantum Switch and the Possible Astrophysical Detection of Homochirality as a Signature of Extraterrestrial Life.

Chimia·2026

Same journal

Shining Light on Chiral Monolayer-protected Metal Clusters.

Chimia·2026

Same journal

Spin Depolarization Mechanisms in Halide Perovskite Semiconductors.

Chimia·2026

Same journal

New Insights into Circularly Polarized Luminescence from Chromium(III) Spin-Flip Emitters.

Chimia·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 16, 2025

Monitoring Protein Adsorption with Solid-state Nanopores

Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

Nanopore Technology: When Proteins Analyse Proteins.

¹School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland. verena.rukes@epfl.ch.

|May 2, 2025

Summary

This summary is machine-generated.

Nanopore sensing offers a novel approach for protein analysis, overcoming limitations of traditional methods. This technology enables biomarker identification and the study of protein function for disease research.

Keywords:

Biomarker detection Hsp70 Nanopores Protein analysis Protein function

More Related Videos

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

Sequencing of mRNA from Whole Blood using Nanopore Sequencing

Sequencing of mRNA from Whole Blood using Nanopore Sequencing

Published on: June 3, 2019

Related Experiment Videos

Last Updated: May 16, 2025

Monitoring Protein Adsorption with Solid-state Nanopores

Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

Sequencing of mRNA from Whole Blood using Nanopore Sequencing

Sequencing of mRNA from Whole Blood using Nanopore Sequencing

Published on: June 3, 2019

Area of Science:

Biotechnology
Molecular Biology
Analytical Chemistry

Background:

Nanopore sensing excels at distinguishing molecular differences and observing molecular processes.
The technology has transformed DNA sequencing via long-read, single-molecule analysis.
Protein analysis faces challenges due to the absence of protein-amplification techniques.

Purpose of the Study:

To explore the application of nanopore sensing in protein analysis.
To demonstrate nanopore-based methods for biomarker identification.
To showcase nanopore analysis of protein function.

Main Methods:

Utilizing nanopore sensing technology for molecular detection.
Applying nanopore analysis to identify disease biomarkers.
Employing nanopore techniques to investigate protein functions.

Main Results:

Nanopore sensing successfully distinguished subtle molecular differences in proteins.
The study presents two distinct examples of nanopore-based protein analysis.
Demonstrated potential for biomarker discovery and functional protein studies.

Conclusions:

Nanopore sensing is a promising technology for advancing protein analysis.
This technique offers solutions to limitations in current protein analysis methods.
Nanopore-based approaches can significantly contribute to understanding cellular functions and diseases.