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Intensive Glycemic Treatment Mitigates Cardiovascular and Mortality Risk Associated With Cardiac Autonomic Neuropathy

Huimin Zhou1,2, Yiquan Huang3, Peihan Xie1,2

  • 1Cardiology Department First Affiliated Hospital of Sun Yat-Sen University Guangzhou China.

Journal of the American Heart Association
|May 2, 2025
PubMed
Abstract

Insights

Intensive glycemic treatment significantly lowers cardiovascular and mortality risks for patients with cardiac autonomic neuropathy (CAN). This approach may effectively manage CAN, a condition linked to higher risks.

Area of Science:

  • Cardiology
  • Endocrinology
  • Diabetology

Background:

  • Hyperglycemia is a potential risk factor for cardiac autonomic neuropathy (CAN).
  • CAN increases cardiovascular and mortality risks.
  • The impact of intensive glycemic treatment on CAN-associated risks is not fully understood.

Purpose of the Study:

  • To investigate if intensive glycemic treatment mitigates cardiovascular and mortality risks in patients with CAN.
  • To analyze the interaction between CAN status and glycemic treatment intensity on cardiovascular and mortality outcomes.

Main Methods:

  • Secondary analysis of 7866 patients from the ACCORDION study.
  • CAN defined by ECG-derived measures.
  • Primary outcome: composite cardiovascular events; secondary outcome: all-cause deaths.

Main Results:

  • Intensive treatment reduced primary outcome and death risks in patients with CAN, but not those without.
  • CAN presence increased risks in the standard treatment group, but not the intensive group.
  • Incidence rates for outcomes were similar for non-CAN patients and CAN patients on intensive treatment.

Conclusions:

  • Intensive glycemic treatment effectively mitigates cardiovascular and mortality risks associated with CAN.
  • Intensive glycemic treatment is a promising strategy for managing CAN.
Keywords:
cardiac autonomic neuropathycardiovascular riskmortality risktype 2 diabetes

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