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Updated: May 17, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
A Two-Step Process for the Synthesis of Densely Functionalized N-Bridged Octahydrobenzofurans and
Xiaodan Han1, Pei Zhao2, Jianjun Yuan3
1Department of Applied Chemistry, Jiang Xi Academy of Sciences, Nanchang 330096, China.
Abstract:
A new process for the synthesis of densely functionalized N-bridged octahydrobenzofurans and hexahydrobenzofurans, by means of a two-step protocol, is reported. The mechanism involves a novel catalytic rearrangement reaction, a Diels-Alder reaction, and an intramolecular aza-addition cyclization. Preliminary bioassays showed that compound 3d more strongly inhibited Staphylococcus aureus, while compound 4d displayed excellent insecticidal activity against Spodoptera litura Fabricius.
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