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A novel assessment of anthracycline-induced cardiotoxicity: topological flow data analysis in childhood cancer survivors

  • 0Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
American Journal of Physiology. Heart and Circulatory Physiology +

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May 2, 2025

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May 2, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Topological flow data analysis (TFDA) detects early cardiotoxicity in childhood cancer survivors treated with anthracyclines. This sensitive method identifies cardiac dysfunction before traditional markers, aiding long-term monitoring.

Area Of Science

  • Cardiology
  • Pediatric Oncology
  • Medical Imaging
  • Fluid Dynamics

Background

  • Anthracycline chemotherapy is vital for childhood cancer survival but causes late-onset cardiotoxicity.
  • Early detection of cardiac dysfunction is crucial for managing chemotherapy side effects.
  • Novel methods are needed to assess subclinical cardiac changes in survivors.

Purpose Of The Study

  • To evaluate Topological Flow Data Analysis (TFDA) for assessing left ventricular flow patterns in childhood cancer survivors (CCSs).
  • To compare TFDA parameters with conventional echocardiographic markers of cardiac function.
  • To investigate the relationship between TFDA findings and anthracycline treatment variables.

Main Methods

  • Analyzed left ventricular flow patterns in 90 CCSs and 90 controls using TFDA.
  • Calculated TFDA parameters: vortex number, size, circulation, mitral inflow width, and saddle points.
  • Compared TFDA parameters across age subgroups (4-12, 13-19, 20-36 years) and correlated with clinical data.

Main Results

  • CCSs showed increased abnormal vortices and reduced systolic/diastolic circulation compared to controls.
  • Reduced mitral inflow width and longitudinal strain were observed in older CCS subgroups.
  • TFDA identified cardiac dysfunction earlier than conventional echocardiography, correlating with age and anthracycline dose.

Conclusions

  • TFDA is a sensitive tool for early detection of anthracycline-induced cardiotoxicity in childhood cancer survivors.
  • TFDA parameters provide insights into age- and dose-dependent cardiac dysfunction.
  • This method supports long-term cardiovascular monitoring and early intervention strategies for high-risk populations.

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