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Updated: May 9, 2025

Author Spotlight: The 3D Culturing of Organoids from Murine Intestinal Crypts and a Single Stem Cell for Organoid Research
Published on: April 7, 2023
Shaping intestinal organoids: Engineering crypt curvature to guide stem cell niches
Riccardo Barrile1, Magdalena Kasendra2
1Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45219, USA; Department of Biomedical Engineering, College of Engineering and Applied Science of the University of Cincinnati, Cincinnati, OH 45219, USA.
Abstract:
Yavitt et al.1 introduce a photodegradable hydrogel platform to control crypt curvature in intestinal organoids, revealing how epithelial morphology directs Paneth cell localization. This innovative approach advances organoid engineering, providing a reproducible method to study stem cell niche interactions and model intestinal development and disease.
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