An Expert Consensus Delphi Panel in Metabolic Dysfunction- and Alcohol-associated Liver Disease: Opportunities and...

Area of Science:

• Hepatology
• Metabolic Diseases
• Alcohol-Related Disorders

Background:

• Metabolic dysfunction- and alcohol-associated liver disease (MetALD) is a recently defined condition with significant clinical and research challenges.
• Current definitions of MetALD present difficulties in practical application and scientific investigation.

Purpose of the Study:

• To establish practical recommendations for the clinical assessment and management of MetALD.
• To address current challenges in the diagnosis and treatment of MetALD through expert consensus.

Main Methods:

• A modified Delphi process involving 2 surveys with 28 international experts.
• Consensus was defined as ≥80% agreement among the expert panel.

Main Results:

• Consensus was reached on 28 statements covering assessment, management, and research needs for MetALD.
• Recommendations include comprehensive patient assessment, use of alcohol biomarkers (e.g., phosphatidylethanol), noninvasive liver disease testing, and multidisciplinary management.
• The need for further research, including longitudinal studies and validation of biomarkers, was highlighted.

Conclusions:

• This Delphi consensus provides clear, actionable recommendations for MetALD assessment and management.
• The findings aim to standardize clinical practice and guide future research in MetALD.
• Expert consensus addresses the unique challenges posed by MetALD, facilitating better patient care.