Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Spinal Cord: Cross-sectional Anatomy

Spinal Cord: Cross-sectional Anatomy

The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Intrinsic regeneration mechanisms of murine lacrimal gland epithelial cells for therapeutic applications in aqueous-deficient dry eye disease.

The ocular surface·2026

Same author

Deciphering melanoma brain metastases: Role of cellular plasticity and metastatic origin.

Biomaterials advances·2026

Same author

Spatial scale of indentation explains shift in ratio between spinal cord gray and white matter stiffness.

Scientific reports·2026

Same author

High incidence of Y-chromosome mosaicism in male and female individuals with mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy.

Epilepsia·2026

Same author

Enhanced clinical assessment of Orofacial Clefts using interactive 3D visualization from Cinematic Rendering.

Dento maxillo facial radiology·2026

Same author

Combining quasi-static and high frequency experiments for the viscoelastic characterization of porcine brain tissue.

Journal of the mechanical behavior of biomedical materials·2026

Search research articles

Related Experiment Video

Updated: May 12, 2025

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Do human brain white matter and brain stem structures show direction-dependent mechanical behavior?

Nina Reiter¹, Sophia Auer², Lucas Hoffmann³

¹Institute of Continuum Mechanics and Biomechanics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, 91058, Germany.

Acta Biomaterialia

|May 2, 2025

Summary

Human brain white matter, including the corpus callosum, exhibits direction-dependent mechanical properties. This study investigates brain tissue mechanics to improve models for diffuse axonal injury and neurological disorder treatment.

Keywords:

Anisotropy Brain stem Corona radiata Corpus callosum Human brain tissue Large strains Mechanical testing

More Related Videos

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Published on: May 23, 2017

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

Related Experiment Videos

Last Updated: May 12, 2025

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Published on: May 23, 2017

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

Area of Science:

Biomechanics
Neuroscience
Materials Science

Background:

Diffuse axonal injury from head impacts affects the corpus callosum and brain stem.
Existing models debate the direction-dependent (anisotropic) mechanical behavior of brain white matter.
Understanding brain tissue mechanics is crucial for injury prevention and neurological disorder treatment.

Purpose of the Study:

To experimentally investigate the large-strain, multimodal mechanical behavior of human brain tissue, specifically the corpus callosum and medulla oblongata.
To determine if these structures exhibit statistically significant direction-dependent mechanical responses.
To compare the mechanical properties of the corpus callosum and medulla oblongata with other white matter and brain stem structures.

Main Methods:

Performed large-strain, multimodal experimental tests (cyclic compression-tension and shear) on human brain tissue.
Tested the corpus callosum and medulla oblongata along two distinct anatomical directions.
Included histological analyses to correlate mechanical findings with tissue microstructure.

Main Results:

The corpus callosum demonstrated statistically significant direction-dependent mechanical behavior.
Directional differences in the medulla oblongata were not statistically significant, showing no clear anisotropy.
Mechanical responses varied across different white matter and brain stem structures, influenced by axonal and cellular architecture.

Conclusions:

The corpus callosum exhibits anisotropic mechanical properties, supporting the need for direction-dependent material models.
Brain stem structures, like the medulla oblongata, showed less pronounced directionality in this study.
Tissue microstructure, including axonal characteristics and architectural organization, significantly influences the mechanical behavior of brain regions.