Corin in cardiovascular diseases and stroke

Corin is a type II transmembrane serine protease highly expressed in the heart. It plays a critical role in regulating fluid balance and improving cardiac function by converting pro-atrial natriuretic peptide into mature atrial natriuretic peptide. CORIN variants have been identified in patients with hypertension, heart failure, atrial fibrillation, and stroke. In vivo and in vitro, corin deficiency increases blood pressure and impairs cardiac function. Circulating soluble corin appears to have potential as a stable and specific biomarker for the risk prediction and prognostic assessment of cardiovascular diseases (CVDs) and stroke. In this review, we summarize the current knowledge on corin physiology and circulating corin and discuss cardiac corin expression and function in CVDs. In the future, corin-related therapeutic approaches to increase corin activity and raise corin levels may offer new opportunities to treat CVDs.