Corin in cardiovascular diseases and stroke

Area of Science:

• Biochemistry
• Cardiovascular Physiology
• Protease Function

Background:

• Corin is a type II transmembrane serine protease predominantly expressed in the heart.
• It processes pro-atrial natriuretic peptide (pro-ANP) to mature atrial natriuretic peptide (ANP), crucial for fluid balance and cardiac function.
• CORIN gene variants are associated with cardiovascular diseases (CVDs) like hypertension, heart failure, atrial fibrillation, and stroke.

Purpose of the Study:

• To review current knowledge on corin physiology and its role in cardiovascular diseases.
• To discuss the significance of cardiac corin expression and function in the context of CVDs.
• To explore the potential of circulating soluble corin as a biomarker for CVD risk and prognosis.

Main Methods:

• Literature review of existing research on corin.
• Analysis of in vivo and in vitro studies investigating corin deficiency.
• Examination of clinical data linking CORIN variants to cardiovascular conditions.

Main Results:

• Corin deficiency leads to increased blood pressure and impaired cardiac function.
• Soluble corin shows promise as a biomarker for predicting cardiovascular disease and stroke risk.
• CORIN variants are implicated in various cardiovascular pathologies.

Conclusions:

• Corin plays a critical role in maintaining cardiovascular homeostasis.
• Circulating corin levels may serve as a valuable biomarker for cardiovascular risk assessment.
• Targeting corin activity presents a potential therapeutic strategy for treating cardiovascular diseases.