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Updated: May 9, 2025
10:27
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
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Circular RNAs modulate cell death in cardiovascular diseases.
Runfang Pan1, Chinying Koo1, Wenyuan Su2
1Department of Anatomy, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Cell Death Discovery
|May 2, 2025
Summary
Circular RNAs (circRNAs) are key regulators of programmed cell death (PCD) in cardiovascular diseases (CVDs). Targeting circRNAs offers promising therapeutic strategies for treating CVDs by modulating cell death pathways.
Area of Science:
- Molecular Biology
- Cardiovascular Research
- Genetics
Background:
- Cardiovascular diseases (CVDs) represent a significant global health burden.
- Programmed cell death (PCD) pathways, including apoptosis and necroptosis, are critical in CVD progression.
Purpose of the Study:
- To explore the role of circular RNAs (circRNAs) in regulating PCD mechanisms within the context of CVDs.
- To highlight the potential of circRNAs as therapeutic targets for CVD treatment.
Main Methods:
- Review of current research on circRNA regulation of PCD.
- Analysis of circRNA mechanisms, including miRNA sponging, protein interactions, and translation.
- Examination of therapeutic strategies involving circRNA manipulation (inhibition/overexpression).
Main Results:
- CircRNAs are increasingly recognized as crucial regulators of gene expression impacting PCD.
- Apoptosis is the most studied PCD mechanism regulated by circRNAs, with growing interest in pyroptosis and necroptosis.
- CircRNAs exert regulatory functions through diverse molecular mechanisms.
Conclusions:
- CircRNAs play a significant role in modulating PCD in CVDs.
- Targeting circRNAs presents a promising avenue for novel therapeutic interventions in cardiovascular medicine.
- Further research into circRNA-mediated pathways is essential for understanding CVD pathophysiology.
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