Related Experiment Video

Updated: May 9, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

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Cellular parameters shaping pathways of targeted protein degradation

Annabel Cardno1, Bryony Kennedy1, Catherine Lindon2

  • 1Department of Pharmacology, University of Cambridge, Cambridge, UK.

Communications Biology
|May 2, 2025
PubMed
Summary

Proteolysis-targeting chimeras (PROTACs) advance targeted protein degradation (TPD). Understanding cellular factors like target location and E3 ligase activity is crucial for designing effective PROTACs.

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