Related Experiment Video
Updated: May 9, 2025
Author Spotlight: A 3D Digital Model for the Diagnosis and Treatment of Pulmonary Nodules
Published on: May 19, 2023
Artificial intelligence-based automated matching of pulmonary nodules on follow-up chest CT
Nicola Fink1,2, Jonathan I Sperl3, Johannes Rueckel4,5
1Department of Radiology, University Hospital, LMU Munich, Munich, Germany. nicola.fink@med.uni-muenchen.de.
Background:
The growing demand for follow-up imaging highlights the need for tools supporting the assessment of pulmonary nodules over time. We evaluated the performance of an artificial intelligence (AI)-based system for automated nodule matching.
Methods:
In this single-center study, patients with nodules and ≤ 2 chest computed tomography (CT) examinations were retrospectively selected. An AI-based algorithm was used for automated nodule detection and matching. The matching rate and the causes for incorrect matching were evaluated for the ten largest lesions (5-30 mm in diameter) registered on baseline CT. The dependence of the matching rate on nodule number and localization was also analyzed.
Results:
One hundred patients (46 females), with a median age of 62 years (interquartile range 57-69), and 253 CTs were included. Focusing on the ten largest lesions, 1,141 lesions were identified, of which 36 (3.2%) were other structures incorrectly identified as nodules (false-positives). Of the 1,105 identified nodules, 964 (87.2%) were correctly detected and matched. The matching rate for nodules registered in both baseline and follow-up scans was 97.8%. The matching rate per case ranged 80.0-100.0% (median 90.0%). Correct matching rate decreased in follow-up examinations to over 50 nodules (p = 0.003), with an overrepresentation of missed matching. Matching rates were higher in parenchymal (91.8%), peripheral (84.4%), and juxtavascular (82.4%) nodules than in juxtaphrenic nodules (71.1%) (p < 0.001). Missed matching was overrepresented in juxtavascular, and incorrect assignment in juxtaphrenic nodules.
Conclusion:
The correct automated-matching rate of metastatic pulmonary nodules in follow-up examinations was high, but it depends on localization and a number of nodules.
Relevance Statement:
The algorithm enables precise follow-up matching of pulmonary nodules, potentially providing a solid basis for standardized and accurate evaluations. Understanding the algorithm's strengths and weaknesses based on nodule localization and number enhances the interpretation of AI-based results.
Key Points:
The AI algorithm achieved a correct nodule matching rate of 87.2% and up to 97.8% when considering nodules detected in both baseline and follow-up scans. Matching accuracy depended on nodule number and localization. This algorithm has the potential to support response evaluation criteria in solid tumor-based evaluations in clinical practice.
