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Related Experiment Video

Updated: May 8, 2025

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Published on: May 19, 2020

Redefining CNS immune privilege.

Leon C D Smyth¹, Jonathan Kipnis²

¹Brain Immunology and Glia Center, Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.

Nature Reviews. Immunology

|May 2, 2025

Summary

This summary is machine-generated.

The central nervous system (CNS) is not isolated but communicates with the immune system via border tissues. Understanding this neuroimmune communication is key for developing immunotherapies for neurological diseases.

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Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

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Last Updated: May 8, 2025

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

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Published on: May 19, 2020

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

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Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Area of Science:

Neuroimmunology
Central Nervous System (CNS) Research
Immune Privilege

Background:

The central nervous system (CNS) was traditionally considered immune privileged due to isolation.
Recent evidence reveals significant neuroimmune communication at CNS border sites.
These border sites facilitate immune surveillance and protection.

Purpose of the Study:

To challenge the isolation theory of immune privilege.
To highlight the role of CNS border tissues in neuroimmune communication.
To emphasize the potential for developing immunotherapies for neurological diseases.

Main Methods:

Review of recent findings on neuroimmune interactions.
Analysis of the role of CNS border tissues (meninges, choroid plexus, vasculature).
Investigation of cerebrospinal fluid as an immune mediator.

Main Results:

Immune privilege is characterized by active communication, not isolation.
CNS border tissues, including meningeal lymphatic vessels, are crucial for immune surveillance.
Cerebrospinal fluid acts as a mediator for immune responses at CNS borders.

Conclusions:

CNS immune privilege is an active accord between the CNS and immune system.
Understanding neuroimmune communication at CNS borders is vital for therapeutic strategies.
This research paves the way for effective immunotherapies for neurological conditions.