Regenerative endodontic procedure using Emdogain: a case series.

Area of Science:

• Biomaterials Science
• Regenerative Dentistry
• Endodontics

Background:

• Emdogain, an enamel matrix derivative, plays a role in odontogenesis and pulp tissue repair.
• Its clinical efficacy as a scaffold in regenerative endodontic procedures (REPs) is not fully understood.
• This study investigates Emdogain's potential in human REPs.

Purpose of the Study:

• To evaluate the clinical and radiographic outcomes of using Emdogain as a scaffold in REPs.
• To assess Emdogain's role in guiding angiogenesis and healing in immature necrotic teeth.
• To report on three distinct clinical cases treated with an identical protocol.

Main Methods:

• Retrospective analysis of three REPs in immature necrotic teeth using Emdogain as a scaffold.
• An identical two-appointment clinical protocol was followed for all cases.
• Clinical and radiographic assessments, including crown shade and pain evaluation, were performed up to 24 months.

Main Results:

• Radiographic lesions resolved by 12 months.
• Apical closure and increased root length were observed at 24 months.
• Dentin wall thickening occurred, with one case showing calcified zones in the root canal.

Conclusions:

• Emdogain may be beneficial as a scaffold in regenerative endodontic procedures.
• Consistent positive outcomes include continued root formation and thickened root dentin walls.
• Complete root apex closure was achieved in all cases at 24-month follow-up.