Oral and intestinal flora translocation and tumor development

Area of Science:

• Microbiology
• Oncology
• Immunology

Background:

• Cancer metastasis is a leading cause of mortality.
• Tumor-associated microflora and the oral-gut axis are increasingly recognized for their role in cancer progression.
• The relationship between host microflora and cancer risk/recurrence is critical but understudied.

Purpose of the Study:

• To review the impact of the oral-gut axis on immunity.
• To explore the link between oral/intestinal flora translocation and the tumor microenvironment.
• To analyze mechanisms of microflora translocation in tumor evolution and development.

Main Methods:

• Systematic review and analysis of PubMed-indexed articles.
• Focus on the oral-gut axis, microbial translocation, and tumor microenvironment.
• Examination of microflora's role in cancer occurrence and progression.

Main Results:

• The oral-gut axis influences the human immune system.
• Translocation of oral and gut microflora is associated with tumor development and the tumor microenvironment.
• Specific mechanisms link microflora changes to tumor evolution and progression.

Conclusions:

• Host microflora is crucial for cancer risk regulation and preventing recurrence.
• Understanding intratumoral microflora mechanisms is essential for comprehensive cancer insights.
• The oral-gut axis and microbial translocation are significant factors in cancer development.