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Generation of Self-assembled Vascularized Human Skin Equivalents
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Functional and molecular insights in topical wound healing by ascorbic acid
Bhawana Jha1, Ankit Majie1, Kankan Roy1
1Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India.
Naunyn-Schmiedeberg'S Archives of Pharmacology
|May 3, 2025
Summary
Ascorbic acid (AA) shows promise for accelerating wound healing by supporting collagen synthesis and tissue regeneration. AA-based therapies offer hope for managing challenging chronic wounds and reducing healthcare costs.
Area of Science:
- Dermatology and Regenerative Medicine
- Biochemistry of Wound Healing
Background:
- Skin integrity relies on complex cellular and molecular repair mechanisms.
- Chronic wounds, often linked to diabetes, present significant clinical challenges.
- Effective wound management requires a deep understanding of wound physiology.
Purpose of the Study:
- To explore the potential of Ascorbic Acid (AA) as a therapeutic agent for wound healing.
- To evaluate the efficacy of AA-based formulations in accelerating tissue regeneration and wound closure.
Main Methods:
- Review of preclinical studies on Ascorbic Acid (AA) formulations for wound healing.
- Analysis of AA's molecular and cellular mechanisms in promoting skin repair.
- Investigation of innovative delivery methods and synergistic combinations for AA application.
Main Results:
- Ascorbic Acid (AA) demonstrated multifaceted benefits, including enhanced collagen synthesis, antioxidant defense, re-epithelialization, and angiogenesis.
- AA formulations showed potential in accelerating wound closure and tissue regeneration in preclinical settings.
- Innovative delivery systems and synergistic combinations with other actives enhance AA's efficacy and biocompatibility.
Conclusions:
- Ascorbic Acid (AA) is a promising agent for advancing wound care, particularly for chronic wounds.
- AA-based therapies offer a potential solution to reduce the healthcare burden associated with chronic wound management.
- Further research into AA applications, including novel delivery systems, is warranted for improved clinical outcomes.
Keywords:
Ascorbic acidChronic woundsMechanistic insightMolecular mechanismsTissue repairWound healingMore Related Videos
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