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Altered Intra-Network Functional Connectivity Predicts the 6-Month Prognosis in Patients With Medication Overuse
Changling Li1, Yang Zhang1, Chengmin Yang2
1Department of Neurology, West China Hospital of Sichuan University, Chengdu, China.
European Journal of Pain (London, England)
|May 3, 2025
Summary
Functional connectivity changes in the brain
Area of Science:
- Neuroimaging
- Neurology
- Brain Connectivity
Background:
- Medication overuse headache (MOH) is linked to altered functional connectivity (FC) in resting-state networks (RSNs).
- Understanding these FC changes is crucial for predicting treatment outcomes in MOH patients.
Purpose of the Study:
- To investigate alterations in intra- and internetwork FC within RSNs in MOH patients.
- To explore the association between neuroimaging findings and six-month prognoses after treatment.
Main Methods:
- A case-control study compared healthy controls with MOH patients.
- FC was assessed at baseline, and patients were categorized by outcome six months after withdrawal and preventive strategies.
- Logistic regression identified independent alterations linked to good outcomes.
Main Results:
- MOH patients showed increased FC in the left middle temporal gyrus (left frontoparietal network).
- Good outcome patients exhibited decreased FC in the left orbital inferior frontal gyrus (left frontoparietal network) compared to poor outcome patients and controls.
- Altered FC in the left orbital IFG was associated with better prognoses and higher baseline headache intensity.
Conclusions:
- Altered functional connectivity in the left orbital inferior frontal gyrus may predict treatment prognosis in MOH.
- These findings suggest potential neuroimaging biomarkers for predicting MOH outcomes.
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