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Mendelian Randomization Identifies Putative Aging-Related Causal Genes With Diagnostic Potential in Ulcerative Colitis

  • 0Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Annals of Human Genetics +

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May 3, 2025

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May 3, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

This study identifies three aging-related genes (IRF1, ME2, ERBB2) causally linked to ulcerative colitis (UC) risk. These genes show diagnostic potential and correlate with immune cell infiltration in UC patients.

Area Of Science

  • Genomics
  • Immunology
  • Gastroenterology

Background

  • Aging-related immunosenescence elevates ulcerative colitis (UC) risk.
  • Identifying aging-related causal genes is crucial for understanding UC pathophysiology.

Purpose Of The Study

  • Identify aging-related causal genes in UC patients.
  • Evaluate their diagnostic value and underlying mechanisms in UC.

Main Methods

  • Analysis of colonic transcriptome, aging-related genes, GWAS, and cis-eQTL data.
  • Utilized Summary-data-based Mendelian randomization (SMR) analysis to identify putative aging-related causal genes (PARCGs).
  • Validated PARCGs expression, diagnostic efficacy, and correlation with immune infiltration.

Main Results

  • Identified 371 aging-related differentially expressed genes (ARDEGs) linked to immunity, inflammation, and senescence.
  • Three PARCGs (IRF1, ME2, ERBB2) were confirmed causally correlated with UC risk.
  • IRF1, ME2, and ERBB2 demonstrated diagnostic potential for UC and correlated with immune cell infiltration.

Conclusions

  • First identification of three aging-related genes (IRF1, ME2, ERBB2) causally linked to UC risk using SMR.
  • These genes possess diagnostic potential for UC.
  • Explored the correlation between these genes and immune infiltration in UC.

Keywords: