Related Experiment Video
Updated: May 9, 2025

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
Published on: March 1, 2015
Association of Dysphonia in Patients With Dysphagia in the United States: A National Database Study
Linh He1, Robin Zhao1, James Curtis1
1Department of Otolaryngology-Head & Neck Surgery, Weill Cornell Medical College, Sean Parker Institute for the Voice, New York, New York, USA.
Objective:
Limited research exists on the prevalence and comorbidity of dysphagia and dysphonia, though prior studies highlight their co-existence in multiple disease cohorts. This study investigates the prevalence of dysphonia in U.S. adults with dysphagia.
Methods:
A cross-sectional study was conducted using the NIH's All of Us Research Program controlled tier dataset (version 7). Multivariate logistic regression and marginal effects (ME) examined the association of dysphonia in U.S. adults with dysphagia.
Results:
Among 266,612 adults, 24,198 had dysphagia (median age, 67 years; 63% female), and 242,414 did not (median age, 58 years; 61% female). Dysphonia was significantly more prevalent in patients with dysphagia (14% vs. 1.9%, p < 0.001). Multivariate analysis showed a 6.78-fold increase in odds of dysphonia with dysphagia (95% CI 6.47-7.11; ME 9.82%). Dysphagia was significantly associated with dysphonia in patients with head and neck cancer (aOR 2.93; ME 13.51%), stroke (aOR 3.71; ME 14.56%), neurodegenerative conditions (aOR 4.34; ME 13.16%), COPD (aOR 4.33; ME 13.35%), ACDF (aOR 5.24; ME 18.90%), and vocal fold abnormalities (aOR 1.40; ME 7.71%).
Conclusion:
Patients with dysphagia had a 6.78-fold increase in odds of having a diagnosis of dysphonia. Otolaryngologists and speech-language pathologists should consider dysphonia assessment in their patients presenting with dysphagia.
More Related Videos
Related Concept Videos
Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Larynx
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids,...
Assessment of Airway, Skin Color, and Use of Accessory Muscles
Introduction
The initial evaluation of a patient's respiratory system...
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Endoscopic Procedures I: Esophagogastroduodenoscopy
During an EGD, the endoscope can be used to:

