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Published on: May 12, 2023
Ligand-Engineering MoS2-Osmium Heterostructure as Highly Active and Specific Peroxidase-Mimic Nanozyme for
Pengyou Zhou1, Xiaorui Lin1, Yuxin Song1
1Capital Medical University, Beijing Key Laboratory of environment and aging, Youan street, Xitoutiao, Beijing, 100054, China.
None:
It is still a challenge to fabricate nanozymes with both of high catalytic activity and specificity. Herein, a ligand engineering method is developed to fabricate osmium (Os) nanocluster-Molybdenum disulfide (MoS2) heterostructure with superior peroxidase-specific activity. It has been verified that polyvinylpyrrolidone (PVP) as ligands can confine amorphous Os nanoclusters growing on the MoS2 nanosheet, mechanism studies indicated that PVP acts as appropriate size-limiting reagent and electronic transmission bridge between of Os and MoS2 which can synergistically improve the peroxidase-specific activity. Moreover, the ligand engineering will not affect the peroxidase-mimic specificity of MoS2-Os. Further, it is found that MoS2-Os possessed superior photothermal conversion efficiency, therefore, MoS2-Os can be used as colorimetric and photothermal dual-mode tags. MoS2-Os combined lateral flow strip is established for breast cancer HER2+ exosomes colorimetric and photothermal detection with superior sensitivity and broader liner range, MoS2-Os based interference-free salivary glucose biosensor is also established with a LOD of 0.1 µM, almost 100-fold sensitivity than that of Glucose Assay Kit. Therefore, this work developed a ligand-engineering strategy to regulate Os nanocluster on MoS2 and improve the peroxidase-specific activity, the multifunctional MoS2-Os nanozyme can be used for accurate and multimode biosensing in varies scenes.
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