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Anti-Infective Polyurethane Dressings via Ultrafast Laser Micro/Nanostructuring.

Liang Jing^1,2, Zexu Zhang³, Zongjing Li³

¹Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Advanced Healthcare Materials

|May 3, 2025

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Laser-fabricated micro/nanostructured polyurethane (PU) dressings significantly boost drug loading, effectively combating bacterial infections and promoting wound healing. These advanced PU dressings offer a promising new strategy for clinical applications.

Area of Science:

Biomaterials Engineering
Nanotechnology
Infectious Disease Research

Background:

Bacteria-associated wound infections pose severe health risks, including systemic inflammatory response (SIRS) and septic shock.
Conventional polyurethane (PU) dressings offer limited protection for contaminated wounds due to their purely shielding function.

Purpose of the Study:

To develop advanced medical dressings with enhanced drug delivery capabilities for wound infections.
To investigate the efficacy of laser-induced micro/nanostructured PU dressings (PU-MS) in combating bacterial infections and promoting wound healing.

Main Methods:

Fabrication of micro/nanostructures in PU dressings using ultrafast laser direct writing with spatiotemporal regulation.
Enhancement of drug loading capacity by embedding clindamycin within the PU films.

Keywords:

antibiotics anti‐infective wound dressing laser direct writing with spatiotemporal regulation polyurethane films ultrafast laser micro/nanostructuring

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In vitro assessment of anti-infective properties against Staphylococcus aureus and in vivo evaluation using a rat skin wound infection model.

Main Results:

Laser treatment increased drug loading capacity by 61 times compared to untreated areas.
PU-MS demonstrated significant Staphylococcus aureus inhibition zones in vitro.
In vivo studies confirmed that PU-MS effectively prevented infection, reduced SIRS, and promoted wound healing in rats.

Conclusions:

Laser-induced micro/nanostructured PU dressings (PU-MS) exhibit excellent mechanical properties, biocompatibility, and potent anti-infective capabilities.
PU-MS represent a novel and effective strategy for developing advanced wound dressings to manage bacterial infections and enhance healing.
These findings highlight the considerable potential of PU-MS for diverse clinical applications in wound management.