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Hybrid Cyclopeptide-Based Chemical Models for Allosteric Disulfide and Amyloid Self-Assembly.

Surya Kant Bhardwaj1, V Haridas1,2

  • 1Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|May 3, 2025
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Summary

This study introduces self-assembling, water-soluble cyclic peptides that form amyloid-like fibrils. Their unique disulfide bond structures offer a versatile platform for designing novel molecular architectures.

Keywords:
allosteric disulfideamyloidmacrocyclepseudopeptideself‐assembly

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Area of Science:

  • Supramolecular Chemistry
  • Peptide Chemistry
  • Biomaterials Science

Background:

  • Cyclic peptides are valuable scaffolds in medicinal chemistry.
  • Self-assembly of peptides into ordered structures is crucial for biomaterial development.
  • Disulfide bonds play a key role in peptide structure and function.

Purpose of the Study:

  • To synthesize and characterize novel disulfide-based hybrid cyclic peptides.
  • To investigate the self-assembly properties and morphology of these macrocycles.
  • To explore the structural features, including hydrogen bonding and disulfide bond geometry, using X-ray crystallography.

Main Methods:

  • Synthesis of isomeric disulfide-based hybrid cyclic peptides with varying ring sizes.
  • Solubility and self-assembly studies.
  • Microscopic investigations (e.g., AFM, TEM) for morphology analysis.
  • Autofluorescence measurements.
  • X-ray crystallography for detailed structural elucidation.

Main Results:

  • Synthesized water-soluble pseudopeptidic macrocycles with a high tendency for self-assembly.
  • Observed amyloid-like fibrillar morphology with intrinsic autofluorescence.
  • Determined the X-ray crystal structure of a 23-membered macrocycle, revealing intramolecular hydrogen bonding and a unique S···O interaction.
  • Identified an allosteric disulfide bond with -LHHook geometry.

Conclusions:

  • The macrocyclic framework serves as an ideal platform for generating diverse disulfide conformations.
  • The self-assembly behavior and structural characteristics of these peptides have implications for designing novel biomaterials and drug delivery systems.
  • Understanding the unique S···O interaction and disulfide bond geometry provides insights into peptide self-organization.