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Updated: Jun 13, 2025

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
Hybrid Cyclopeptide-Based Chemical Models for Allosteric Disulfide and Amyloid Self-Assembly
Surya Kant Bhardwaj1, V Haridas1,2
1Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India.
Abstract:
We present here a series of isomeric disulfide-based hybrid cyclic peptides with different ring sizes. The water soluble pseudopeptidic macrocycles display a high intrinsic tendency to self-assemble. Microscopic investigations revealed amyloid like fibrillar morphology with autofluorescence. X-ray crystal structure of 23-membered macrocycle showed the presence of intramolecular hydrogen bonding and a unique S···O interaction. We delineate that the macrocyclic framework is an ideal platform to generate various classes of disulfide conformations. X-ray structure of the macrocycle further revealed the presence of an allosteric disulfide bond with -LHHook geometry.
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