Sarcopenia and intrinsic capacity in older adults: A systematic review

Sarcopenia and intrinsic capacity are closely linked factors that impact the health and functional aging of older adults.

This systematic review aims to investigate the associations between the domains of IC and sarcopenia in older adults.

The study follows PRISMA guidelines and is registered on PROSPERO. The review included original studies (cohort, cross-sectional, or randomized controlled trials) with participants aged 60+ diagnosed with sarcopenia (based on EWGSOP or other recognized definitions). Intrinsic capacity (IC) was assessed based on the five domains defined within the IC framework-cognition, locomotion, sensory, psychological, and vitality. The Integrated Care for Older People (ICOPE) approach developed by the World Health Organization supports the optimization of IC and functional ability through person-centred and coordinated care. Exclusion criteria included studies with insufficient data on sarcopenia prevalence and IC scores, as well as reviews or studies unrelated to sarcopenia or IC.

A total of 397 articles were identified, with 5 meeting the inclusion criteria. These studies, involving 6651 participants aged 60 to 82 years (54.8 % male, 45.2 % female), examined the association between sarcopenia and intrinsic capacity in older adults, using the diagnostic criteria for sarcopenia proposed by the EWGSOP and assessing IC based on its key components. Despite the limited number of studies, the findings suggest a significant link between declining intrinsic capacity and sarcopenia.

These results underscore the importance of a multifactorial approach in assessing and managing sarcopenia, which may improve early detection and support healthy aging.