Nanochannel functionalization using POFs: Progress and prospects

Biomimetic nanochannels, inspired by natural ion channels found in living organisms, are synthetic systems designed to replicate the highly selective and efficient ion/molecule transport processes essential for various biological functions. These artificial channels mimic the structural and functional properties of their biological counterparts, offering precise control over ion and molecular transport. Porous organic framework materials (POFs), including metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), have emerged as promising materials for functionalizing nanochannels due to their unique structures and exceptional properties. This functionalization strategy not only enhances the performance of synthetic nanochannels but also broadens their application potential across various fields. This review comprehensively examines the recent progress in the preparation and application of POFs stereoscopic-functionalized solid nanochannels. Special emphasis is placed on their practical applications, including proton conduction, ion-selective membranes, photo-responsive materials, sensing and detection, chiral separation, and catalysis. Finally, the future development prospects and challenges in this research area are discussed, highlighting opportunities for advancing the design and application of biomimetic nanochannels.