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Updated: May 20, 2025

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
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Evolving dynamics in clinical trials for oral cancer: Trends, treatment modalities, and future directions

Yihao Pei1, Ziqi Yang1, Yiming Mao2

  • 1Medical College of Jinzhou Medical University, Jinzhou 121000, China.

Oral Oncology
|May 3, 2025
PubMed
Abstract

Insights

Clinical trial research increased steadily until 2021, with a focus on early-phase safety and efficacy. Drug interventions, especially immunotherapy, are prominent, necessitating further large-scale trials for validation.

Area of Science:

  • Oncology
  • Clinical Pharmacology

Background:

  • Analysis of clinical trials from 2004-2024 shows a consistent rise in research activity.
  • A significant trend towards early-phase trials evaluating safety and preliminary efficacy has been observed.

Purpose of the Study:

  • To analyze trends in clinical trial research over two decades.
  • To identify dominant intervention types and emerging therapeutic strategies.

Main Methods:

  • Retrospective analysis of clinical trial data from 2004 to 2024.
  • Identification and categorization of intervention types, including specific drugs and therapeutic modalities.

Main Results:

  • Clinical trial research peaked in 2021, with a notable increase in early-phase studies.
  • Drug-based interventions, including Cisplatin, Ixazomib, and Dexamethasone, are most common.
  • A growing trend towards immunotherapy, with Pembrolizumab as a key agent, is evident in recent years.

Conclusions:

  • Future research should prioritize large-scale, long-term clinical trials.
  • Validation of emerging therapies, particularly immunotherapies, is crucial.
  • Exploration of combination therapies integrating immunotherapy with other treatment modalities is recommended.

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