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Updated: May 3, 2026

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Clinical trajectories in liver cirrhosis: An evidence-based reappraisal for the internist
Rosa Zampino1, Fabian Patauner2, Emanuele Durante-Mangoni3
1Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", P.zza L. Miraglia 2, 80138 Napoli, Italy; Unit of Internal Medicine & Transplants, A.O.R.N. Ospedali dei Colli - Ospedale Monaldi, Piazzale Ettore Ruggieri, 80131 Napoli Italy.
Abstract:
Over the last few years, the approach to clinical recognition and risk stratification of advanced liver disease has changed substantially, and liver cirrhosis has been increasingly conceptualized as a clinical rather than a histopathologic condition. In this Clinical Insight, we summarize the latest developments on recognition and management of 'clinically' advanced chronic liver disease.
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