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Updated: Aug 10, 2026

GC-based Detection of Aldononitrile Acetate Derivatized Glucosamine and Muramic Acid for Microbial Residue Determination in Soil
Published on: May 19, 2012
Preparation of glucosidic derivatives of steganol
Abstract:
Glucoside derivatives of steganol analogous to the semisynthetic podophyllotoxin derivative, VP 16-213, were prepared. Glucosidation of steganol with 2, 3, 4, 6-tetra-O-benzylglucopyranose gave the alpha-anomer of the glucoside as the major product. Subsequent removal of the benzyl groups and reaction with acetaldehyde dimethyl acetal gave the ethylidene derivative 10. The beta-anomer of the glucoside was similarly converted to 12. All derivatives prepared were screened for activity in the DNA breakage assay.
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