Related Experiment Video
Updated: May 12, 2025

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
Genetic ancestry and population structure in the All of Us Research Program cohort
Shivam Sharma1,2, Shashwat Deepali Nagar1, Priscilla Pemu3,4
1School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Abstract:
We analyzed participant genomic variant data to characterize population structure and genetic ancestry for the All of Us cohort (n = 297,549). There is substantial population structure in the cohort, with clusters of closely related participants interspersed among less related individuals. Participants show diverse genetic ancestry, with major contributions from European (66.4%), African (19.5%), Asian (7.6%), and American (6.3%) continental ancestry components. Participant genetic similarity clusters show group-specific ancestry, with distinct patterns of continental and subcontinental ancestry among groups. African and American ancestry are enriched in the southeast and southwest regions of the country, respectively, whereas European ancestry is more evenly distributed across the US. The diversity of All of Us participants' genetic ancestry is negatively correlated with age; younger participants show higher levels of genetic admixture compared to older participants. Our results underscore the ancestral genetic diversity of the All of Us cohort, a crucial prerequisite for genomic health equity.
More Related Videos
05:53Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
09:38Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
Related Concept Videos
What is Population Genetics?
Behavioral Genetics and Its Designs
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Longitudinal Studies
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Genetic Variation
Genes exist in different versions called alleles,...
Longitudinal Research