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Wheezing on admission: a marker for bronchiolitis severity and asthma development
Patricio Astudillo1, Maria Rodriguez-Fernandez2, José A Castro-Rodríguez3
1Laboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Departamento de Enfermedades Infecciosas e Inmunología Pediátrica, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Pediatric Research
|May 3, 2025
Summary
Wheezing status in infants hospitalized with bronchiolitis predicts severe illness and long-term respiratory issues like asthma. This simple bedside assessment aids clinical decisions and early risk identification for better patient outcomes.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
- Clinical Pediatrics
Background:
- Bronchiolitis is a common respiratory infection in infants.
- Clinical characteristics at hospital admission aid in predicting outcomes.
- Wheezing status is a key factor in stratifying bronchiolitis patients.
Purpose of the Study:
- To evaluate the utility of wheezing status for stratifying hospitalized bronchiolitis patients.
- To determine if wheezing status predicts short-term and long-term respiratory outcomes.
- To identify risk factors associated with wheezing and non-wheezing groups.
Main Methods:
- A prospective cohort study of 668 infants under 2 years old hospitalized with bronchiolitis.
- Patients were categorized by wheezing status at admission.
- Monitoring occurred during hospitalization and for 4 years post-discharge.
Main Results:
- Infants with wheezing experienced more severe illness and required more oxygen.
- Wheezing infants had a higher likelihood of developing preschool wheezing and asthma.
- Risk factors for persistent asthma varied between wheezing and non-wheezing groups.
Conclusions:
- Wheezing status at admission is a valuable tool for stratifying bronchiolitis patients.
- This stratification aids in predicting clinical outcomes and identifying infants at risk for severe respiratory illnesses.
- A bedside wheezing assessment can improve individualized clinical decisions and long-term management.
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